Journal Articles
Each entry analyzes one primary study behind cardiovascular prevention — the trials, genetic studies, and cohorts that built the evidence base. We explain what it found, why it matters, and how much weight it deserves, rating every source for evidence strength and clinical significance.
388 analyses
Coronary Artery Anomalies in Patients with a Zero Calcium Score
Abdalla et al., 2020 · Retrospective cross-sectional imaging study
Image Quality for High Heart Rates in Coronary CT Angiography: the CONVERGE Registry
Abdelkarim et al., 2023 · Prospective observational multicenter cohort study
Mutations in PCSK9 Cause Autosomal Dominant Hypercholesterolemia
Abifadel et al., 2003 · Genetic linkage study
Sudden Cardiac Death: Epidemiology and Risk Factors
Adabag et al., 2010 · Narrative review
Risks of Incident Cardiovascular Disease With Concomitant Elevations in Lipoprotein(a) and LDL Cholesterol — The Framingham Heart Study
Afshar et al., 2020 · Prospective cohort study
Non-HDL Cholesterol, Apolipoprotein B, and HDL Cholesterol With Risk of Sudden Cardiac Death: the ARIC Study
Agarwal et al., 2012 · Prospective cohort study
Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy (AIM-HIGH)
AIM-HIGH Investigators, 2011 · Randomized controlled trial
Percutaneous Coronary Intervention in Stable Angina (ORBITA)
Al-Lamee et al., 2018 · Double-blind randomized placebo-controlled trial
Effect of EPA and DHA Added to Statin Therapy on Coronary Artery Plaque in Patients With CAD
Alfaddagh et al., 2017 · Randomized controlled trial
OCT Compared With IVUS and Angiography to Guide Coronary Stent Implantation (ILUMIEN III: OPTIMIZE PCI)
Ali et al., 2016 · Randomized controlled trial
Major Outcomes in High-Risk Hypertensive Patients Randomized to ACE Inhibitor or Calcium Channel Blocker vs Diuretic (ALLHAT)
ALLHAT Collaborative Research Group, 2002 · Randomized controlled trial
Pravastatin vs Usual Care in Hypertensive Patients With Moderate Hypercholesterolemia (ALLHAT-LLT)
ALLHAT Officers and Coordinators, 2002 · Randomized controlled open-label trial
Incidence of ASCVD in Young Adults at Low Short-Term but High Long-Term Risk
An et al., 2023 · Retrospective cohort study
Coronary CT Angiography as a 'One-Stop Shop' to Detect the High-Risk Plaque and the Vulnerable Patient
Antoniades and West, 2021 · Commentary
Leisure Time Physical Activity and Mortality: A Detailed Pooled Analysis of the Dose-Response Relationship
Arem et al., 2015 · Pooled cohort analysis
Impact of Exercise on the Relationship Between CAC Scores and All-Cause Mortality
Arnson et al., 2017 · Prospective observational cohort study
Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis
Arsenault et al., 2014 · Prospective cohort with Mendelian randomization
Efficacy and Safety of More Intensive Lowering of LDL Cholesterol: A Meta-Analysis of 26 Randomised Trials
Baigent et al., 2010 · Meta-analysis
Myocardial Viability Assessment During Impella Support With 18-FDG PET Imaging
Baldetti et al., 2025 · Case series
Long-Term Safety and Efficacy of Bempedoic Acid: CLEAR Harmony Open-Label Extension
Ballantyne et al., 2022 · Phase 3 open-label extension
VLDL Cholesterol Accounts for One-Half of the Risk of Myocardial Infarction Associated With apoB-Containing Lipoproteins
Balling et al., 2020 · Prospective cohort study
Statin–Ezetimibe Combination Therapy vs Statin Monotherapy on Cardiovascular Outcomes: A Meta-Analysis
Banach et al., 2025 · Meta-analysis
Worldwide Prevalence of Familial Hypercholesterolemia: Meta-Analyses of 11 Million Subjects
Beheshti et al., 2020 · Systematic review and meta-analysis
Improving Prediction of Ischemic Cardiovascular Disease Using Apolipoprotein B: the Copenhagen City Heart Study
Benn et al., 2007 · Prospective cohort study
Association Between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults (Bogalusa Heart Study)
Berenson et al., 1998 · Autopsy study with antemortem risk factor assessment
A New Serum Type System in Man — the Lp System
Berg, 1963 · Original research (case series)
A Novel Function of Lipoprotein(a) as a Preferential Carrier of Oxidized Phospholipids in Human Plasma
Bergmark et al., 2008 · Laboratory / mechanistic study
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
Bergström et al., 2021 · Cross-sectional population study
Apolipoproteins as Predictors of Ischaemic Stroke in Patients With a Previous Transient Ischaemic Attack
Bhatia et al., 2006 · Prospective cohort study
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT)
Bhatt et al., 2019 · Randomized controlled trial
Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
Bittner et al., 2020 · Pre-specified analysis of randomized trial
Optimal Medical Therapy With or Without PCI for Stable Coronary Disease (COURAGE)
Boden et al., 2007 · Randomized controlled trial
Niacin in Patients With Low HDL Cholesterol Levels Receiving Intensive Statin Therapy (AIM-HIGH)
Boden et al., 2011 · Randomized controlled trial
Increased Stroke Risk and Lipoprotein(a) in a Multiethnic Community: The Northern Manhattan Stroke Study
Boden-Albala et al., 2010 · Case-control study
LDL, Non-HDL Cholesterol, and Apolipoprotein B and Risk of Cardiovascular Events in Statin-Treated Patients: A Meta-Analysis
Boekholdt et al., 2012 · Meta-analysis
Apolipoprotein(a) Gene Accounts for Greater Than 90% of the Variation in Plasma Lipoprotein(a) Concentrations
Boerwinkle et al., 1992 · Genetic / family study
Functional Outcome After Revascularization in Chronic Ischemic Heart Disease: A Late Gadolinium Enhancement CMR Study
Bondarenko et al., 2007 · Prospective imaging study
Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve
Bouchareb et al., 2015 · Mechanistic / translational study
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis
Bourgeois et al., 2020 · Case-control study with biochemical analyses
Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Pathways Linking Lp(a) to Aortic Stenosis
Bourgeois et al., 2021 · Multi-omic observational study
Calcium Scoring Improves Clinical Management in Patients With Low Clinical Likelihood of Coronary Artery Disease
Brix et al., 2024 · Retrospective cohort study
Association Between IVUS Findings and Adverse Outcomes in Coronary Artery Disease (VIVA Study)
Calvert et al., 2011 · Prospective cohort study
Ezetimibe Added to Statin Therapy After Acute Coronary Syndromes (IMPROVE-IT)
Cannon et al., 2015 · Randomized controlled trial
Prevalence, Clinical Characteristics, and Mortality Among Patients With Myocardial Infarction Presenting Without Chest Pain
Canto et al., 2000 · Prospective cohort study
Apolipoprotein B Discordance With LDL and Non-HDL Cholesterol in Relation to Coronary Artery Calcification (MESA)
Cao et al., 2020 · Prospective cohort study
Accuracy and Limitation of Plaque Detection by Coronary CTA: A Comparison With Optical Coherence Tomography
Cao et al., 2023 · Diagnostic accuracy study
Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis
Capoulade et al., 2015 · Prospective cohort study
ApoCIII-Lp(a) Complexes With Lp(a)-OxPL Predict Rapid Progression of Aortic Stenosis
Capoulade et al., 2020 · Prospective cohort study with molecular analyses
How Early Can Atherosclerosis Be Detected by Coronary CT Angiography? Insights From the PARADIGM Trial
Cardoso et al., 2023 · Retrospective observational study
Association of Coronary Artery Calcium in Adults Aged 32 to 46 Years With Incident Coronary Heart Disease and Death
Carr et al., 2017 · Prospective cohort study
Prevention of Venous Thrombosis in Long-Haul Flights With Flite Tabs (LONFLIT-FLITE)
Cesarone et al., 2003 · Randomized controlled trial
Lipoprotein(a) in Type 2 Diabetic Subjects and Its Relationship to Diabetic Microvascular Complications
Chandni and Ramamoorthy, 2012 · Cross-sectional study
Cerebellar Hemorrhage Provoked by Combined Use of Nattokinase and Aspirin in a Patient With Cerebral Microbleeds
Chang et al., 2008 · Case report
Effects of Natto Extract on Endothelial Injury in a Rat Model
Chang et al., 2010 · Experimental animal and in vitro study
Chen and Wang, 2020 (BMJ Open Diabetes Research & Care)
Chen and Wang, 2020
Management of Atherosclerosis Progress and Hyperlipidemia With Nattokinase: A Clinical Study With 1,062 Participants
Chen et al., 2022 · Retrospective clinical study
IVUS-Guided vs Angiography-Guided Stent Implantation in Complex Coronary Lesions (AVIO)
Chieffo et al., 2013 · Randomized controlled trial
Quantifying the Contribution of Lipoprotein(a) to All apoB-Containing Particles
Chilazi et al., 2022 · Cross-sectional database analysis
Efficacy and Safety of LDL-Lowering Therapy Among Men and Women: Meta-Analysis of 174,000 Participants
Cholesterol Treatment Trialists' Collaboration, 2015 · Meta-analysis of randomized trials
Coronary Artery Calcium Score, Risk Factors, and Incident Coronary Heart Disease Events
Church et al., 2007 · Prospective cohort study
Genetic Variants Associated With Lp(a) Lipoprotein Level and Coronary Disease
Clarke et al., 2009 · Genetic association study
Low LDL Cholesterol in Individuals of African Descent Resulting From Frequent Nonsense Mutations in PCSK9
Cohen et al., 2005 · Genetic association study
Variance in the Composition and Number of VLDL and LDL Particles With Increasing Triglyceride or ApoB Concentrations
Cole et al., 2025 · Observational cohort analysis
Reference Intervals for Plasma Apolipoprotein B: Results From the Framingham Offspring Study
Contois et al., 1996 · Cross-sectional study
Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals: The PESA Study
Cortes-Canteli et al., 2021 · Prospective cohort study
LDL Particle Number and Risk of Future Cardiovascular Disease in the Framingham Offspring Study
Cromwell et al., 2007 · Prospective cohort study
Efficacy and Safety of More Intensive Lowering of LDL Cholesterol: A Meta-Analysis of 26 Randomised Trials
CTT Collaboration, 2010 · Meta-analysis of randomized trials
A Novel Approach to Measuring Macrophage-Specific Reverse Cholesterol Transport In Vivo in Humans
Cuchel et al., 2017 · Feasibility study
Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome
Day et al., 2018 · Genome-wide meta-analysis
Fractional Flow Reserve–Guided PCI Versus Medical Therapy in Stable Coronary Disease (FAME 2)
De Bruyne et al., 2012 · Randomized controlled trial
Parametric Imaging of Myocardial Viability Using 15O-Labelled Water and PET/CT
de Haan et al., 2012 · Validation study
Intravascular Ultrasound-Guided Optimized Stent Deployment (MUSIC Study)
de Jaegere et al., 1998 · Prospective observational study
Mediterranean Diet and the Rate of Cardiovascular Complications After Myocardial Infarction (Lyon Diet Heart Study)
de Lorgeril et al., 1999 · Randomized controlled trial
Diagnostic Performance of Combined Cardiac MRI for Detection of Coronary Artery Disease
de Mello et al., 2012 · Diagnostic accuracy study
Modified Calcium Subtraction in Dual-Energy CT Angiography of the Lower Extremity Runoff
De Santis et al., 2019 · Retrospective diagnostic accuracy study
Women Who Experience a Myocardial Infarction at a Young Age Have Worse Outcomes Compared With Men (YOUNG-MI)
DeFilippis et al., 2020 · Retrospective cohort study
Representation of Women in Cardiovascular Clinical Trial Leadership
Denby et al., 2020 · Cross-sectional study
Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups (MESA)
Detrano et al., 2008 · Prospective cohort study
Major Lipids, Apolipoproteins, and Risk of Vascular Disease
Di Angelantonio et al., 2009 · Meta-analysis
Lipid-Related Markers and Cardiovascular Disease Prediction
Di Angelantonio et al., 2012 · Meta-analysis
Common Variants Associated With Plasma Triglycerides and Risk for Coronary Artery Disease
Do et al., 2013 · Mendelian randomization / GWAS
Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia
Döbert et al., 2021 · Randomized controlled trial
Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk
Domanski et al., 2020 · Prospective cohort study
Simvastatin Alleviates Pathology in a Rat Model of Preeclampsia Involving the ERK/MAPK Pathway
Dong et al., 2017 · Animal study
One-Year Disability Trajectories and Long-Term Cardiovascular Events, Recurrent Stroke, and Mortality After Ischemic Stroke
Du et al., 2024 · Prospective cohort study
DuBroff, 2019 (BMJ Evidence-Based Medicine)
DuBroff, 2019 · Commentary
Family History and Lipoprotein(a) Contribute Independently to Risk Assessment and Clinical Management
Durrington, 2020 · Editorial commentary
Warranty Period of a Calcium Score of Zero: Comprehensive Analysis From MESA
Dzaye et al., 2020 · Prospective cohort analysis
Temporal Trends and Interest in Coronary Artery Calcium Scoring Over Time: An Infodemiology Study
Dzaye et al., 2021 · Infodemiology study
Consequence of Patient Substitution of Nattokinase for Warfarin After Mechanical Aortic Valve Replacement
Elahi et al., 2015 · Case report
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels
Emdin et al., 2016 · Mendelian randomization
Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular Mortality
Emerging Risk Factors Collaboration, 2009 · Meta-analysis
Statins and Lp(a) — The Plot Thickens
Enkhmaa and Berglund, 2019 · Editorial commentary
Apolipoprotein B Outperforms LDL Particle Number as a Marker of Cardiovascular Risk in the UK Biobank
Epstein et al., 2025 · Prospective cohort study
Prevalence and Extent of Coronary Artery Disease Determined by 64-Slice CTA in Patients With a Zero Coronary Calcium Score
Ergün et al., 2011 · Retrospective diagnostic imaging study
Serum Pharmacokinetics of Nattokinase in Humans Following a Single Oral Daily Dose
Ero et al., 2013 · Pilot clinical trial
Primary Prevention of Cardiovascular Disease With a Mediterranean Diet (PREDIMED)
Estruch et al., 2018 · Randomized controlled trial
Serrapeptase and Nattokinase Intervention for Relieving Alzheimer's Disease Pathophysiology in a Rat Model
Fadl et al., 2013 · Animal study
Effect of Long-Term Exposure to Lower LDL Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease
Ference et al., 2012 · Mendelian randomization
Triglyceride-Lowering LPL Variants and LDL-Lowering LDLR Variants With Risk of Coronary Heart Disease
Ference et al., 2019 · Mendelian randomization
The Atherosclerotic Profile of a Young Symptomatic Population: Coronary CT Angiography or Calcium Score?
Feuchtner et al., 2021 · Retrospective cohort study
Test of Effect of Lipid Lowering by Diet on Cardiovascular Risk (The Minnesota Coronary Survey)
Frantz et al., 1989 · Randomized controlled trial
Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat
Fujita et al., 1995 · Animal study
Vitamin K Intake From Natto and Bone Mineral Density in Elderly Japanese Men (FORMEN Study)
Fujita et al., 2012 · Cross-sectional study
IVUS-Guided Bail-Out Stent Implantation for Iatrogenic Aortocoronary Dissection: A Case Report
Fukui and Ogasawara, 2023 · Case report
Coronary CT Angiography and Stress Echocardiography With Long-Term Cardiac Outcome: A Comparison Study
Gaibazzi et al., 2023 · Retrospective cohort study
Data Recorded in Real Life Support the Safety of Nattokinase in Patients With Vascular Diseases
Gallelli et al., 2021 · Prospective observational study
Effects of Insulin Resistance and Type 2 Diabetes on Lipoprotein Subclass Particle Size and Concentration (NMR)
Garvey et al., 2003 · Cross-sectional study
Deep Learning to Classify AL Versus ATTR Cardiac Amyloidosis MR Images
Germain et al., 2023 · Retrospective diagnostic study
Rationale and Design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II)
Gibson et al., 2021 · Trial protocol
Clinical Efficacy and Safety of Evolocumab in High-Risk Patients With Low LDL or on Maximal-Potency Statin (FOURIER Secondary Analysis)
Giugliano and Keech et al., 2017 · Secondary analysis of RCT
Clinical Efficacy and Safety of Achieving Very Low LDL With Evolocumab (FOURIER Secondary Analysis)
Giugliano et al., 2017 · Randomized controlled trial (prespecified secondary analysis)
Rosuvastatin for Primary Prevention in Older Individuals With High C-Reactive Protein and Low LDL (JUPITER Analysis)
Glynn et al., 2010 · Secondary analysis of randomized controlled trial
Impact of Coronary Artery Calcification on All-Cause Mortality in Individuals With and Without Hypertension
Graham et al., 2012 · Prospective cohort study
Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality: The CAC Consortium
Grandhi et al., 2020 · Multicenter cohort study
Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes
Gudbjartsson et al., 2019 · Case-control with Mendelian randomization
Ultra-High-Resolution Photon-Counting Detector CT in Evaluating Coronary Stent Patency
Hagar et al., 2024 · Comparative diagnostic study
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab
Hagström et al., 2022 · Post-hoc analysis of randomized controlled trial
EPA and DHA Supplementation and Coronary Artery Calcium Progression in Patients With CAD
Hariri et al., 2023 · Randomized controlled trial (secondary analysis)
Antioxidative Effect of Crude Antioxidant Preparation From Soybean Fermented by Bacillus natto
Hattori et al., 1995 · In vitro study
MRC/BHF Heart Protection Study of Cholesterol Lowering With Simvastatin in 20,536 High-Risk Individuals
Heart Protection Study Collaborative Group, 2002 · Randomized controlled trial
Hecht et al., 2005 (American Heart Journal)
Hecht et al., 2005
Premature Atherosclerosis Associated With Monogenic Insulin Resistance
Hegele, 2001 · Observational study
Lower Extremity Arterial Disease: Multidetector CT Angiography Meta-Analysis
Heijenbrok-Kal et al., 2007 · Meta-analysis
PCSK9 Inhibitor Therapy: Payer Approvals and Rejections, and Patient Characteristics for Successful Prescribing
Hess et al., 2017 · Retrospective cohort study
Nattokinase Atherothrombotic Prevention Study: A Randomized Controlled Trial
Hodis et al., 2021 · Randomized controlled trial
Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels
Hoekstra et al., 2021 · Genome-wide association study
Effect of Gliadin on Permeability of Intestinal Biopsy Explants From Celiac and Non-Celiac Gluten Sensitivity Patients
Hollon et al., 2015 · Controlled clinical trial (ex vivo)
Comparative Analysis of Apolipoprotein B and LDL Cholesterol for Estimating CHD Risk in Established Coronary Disease
Holme et al., 2010 · Post-hoc analysis of RCTs
IVUS-Guided vs Angiography-Guided Everolimus-Eluting Stent Implantation (IVUS-XPL)
Hong et al., 2015 · Randomized controlled trial
Effects of an ACE Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients (HOPE)
HOPE Study Investigators, 2000 · Randomized controlled trial
Lipoprotein(a) Genetic Variants Associated With Coronary and Peripheral Vascular Disease But Not Stroke (Heart Protection Study)
Hopewell et al., 2011 · Genetic epidemiology study
Impact of Lipoprotein(a) Levels and Apolipoprotein(a) Isoform Size on Risk of Coronary Heart Disease
Hopewell et al., 2014 · Case-control study
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment (SAMSON)
Howard et al., 2021 · Randomized crossover trial
Effects of Extended-Release Niacin With Laropiprant in High-Risk Patients (HPS2-THRIVE)
HPS2-THRIVE Collaborative Group, 2014 · Randomized controlled trial
Amyloid-Degrading Ability of Nattokinase From Bacillus subtilis natto
Hsu et al., 2009 · In vitro study
Prevalence of Familial Hypercholesterolemia Among the General Population and Patients With ASCVD: A Systematic Review and Meta-Analysis
Hu et al., 2020 · Systematic review and meta-analysis
Prediction of Future Cardiovascular Disease With an Equation to Estimate Apolipoprotein B (TNT and IDEAL)
Hwang et al., 2017 · Post-hoc analysis of RCTs
Annual Rate of Coronary Artery Calcification With PCSK9 Inhibitor Plus Statin Versus Statin Monotherapy
Ikegami et al., 2018 · Retrospective cohort study
Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither Among 17,187 Cases of Suspected Acute Myocardial Infarction (ISIS-2)
ISIS-2 Collaborative Group, 1988 · Randomized controlled trial
Antioxidative Functions of Natto: Effect on LDL Oxidation and Lipid Metabolism in Cholesterol-Fed Rats
Iwai et al., 2002 · Animal study
Nattokinase Improves Blood Flow by Inhibiting Platelet Aggregation and Thrombus Formation
Jang et al., 2013 · Animal study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
Jastreboff et al., 2022 · Randomized controlled trial
Distribution of Coronary Artery Calcium by Age, Sex, and Race Among Patients 30–45 Years Old
Javaid et al., 2022 · Cross-sectional cohort study
Mechanisms of Nattokinase in Protection of Cerebral Ischemia
Ji et al., 2014 · Animal study
Association Between LDL Cholesterol and All-Cause and Cause-Specific Mortality in Denmark
Johannesen et al., 2020 · Prospective cohort study
Apolipoprotein B and Non-HDL Cholesterol Better Reflect Residual Risk Than LDL Cholesterol in Statin-Treated Patients
Johannesen et al., 2021 · Prospective cohort study
Excess Apolipoprotein B and Cardiovascular Risk in Women and Men
Johannesen et al., 2024 · Prospective cohort study
Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
Kamstrup et al., 2009 · Mendelian randomization
Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population
Kamstrup et al., 2014 · Mendelian randomization study
Korean Red Ginseng Combined With Nattokinase Ameliorates Dyslipidemia and Aortic Plaque in High-Cholesterol-Diet Rabbits
Kang et al., 2014 · Animal study
Association of Soy and Fermented Soy Product Intake with Total and Cause-Specific Mortality
Katagiri et al., 2020 · Prospective cohort study
Natto Consumption Suppresses Atherosclerotic Plaque Progression in LDL Receptor-Deficient Mice
Kawamata et al., 2023 · Animal study
Incomplete source record
Khan and Khan, 2020 · Unknown
Ten-Year Trends in Enrollment of Women and Minorities in Pivotal Cardiometabolic Trials
Khan et al., 2020 · Cross-sectional analysis
Association of Women Authors with Women Enrollment in Clinical Trials of Atrial Fibrillation
Khan et al., 2022 · Meta-analysis
The Use of Contrast-Enhanced Magnetic Resonance Imaging to Identify Reversible Myocardial Dysfunction
Kim et al., 2000 · Prospective cohort study
Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial
Kim et al., 2008 · Randomized controlled trial
Randomized Comparison of Clinical Outcomes Between IVUS and Angiography-Guided DES Implantation for Long Coronary Artery Stenoses
Kim et al., 2013 · Randomized controlled trial
N-Acetylcysteine Increases Corneal Endothelial Cell Survival in a Mouse Model of Fuchs Endothelial Corneal Dystrophy
Kim et al., 2014 · Animal study
Left Heart Catheterization Using the Single Catheter Radial Approach with the Multipurpose Catheter
Kindya et al., 2022 · Technical report
Catheter-Induced Coronary Artery and Aortic Dissections: Mechanisms, Risk Factors and Propagation
Klaudel et al., 2024 · Retrospective cohort study
Accelerated Cardiac MRI with Deep Learning-Based Image Reconstruction for Cine Imaging
Klemenz et al., 2024 · Prospective cohort study
Cardiac and Respiratory Motion Correction for Simultaneous Cardiac PET/MR
Kolbitsch et al., 2017 · Technical validation study
Eicosapentaenoic Acid Therapy Is Associated with Decreased Coronary Plaque Instability Assessed Using Optical Frequency Domain Imaging
Konishi et al., 2019 · Retrospective cohort study
Preclinical Development and Phase 1 Trial of a Novel siRNA Targeting Lipoprotein(a)
Koren et al., 2022 · Phase 1 clinical trial
Apolipoprotein(a) Size Heterogeneity Is Related to Variable Number of Repeat Sequences in Its mRNA
Koschinsky et al., 1990 · In vitro study
Apolipoprotein A-I-Mediated Efflux of Sterols from Oxidized LDL-Loaded Macrophages
Kritharides et al., 1995 · Laboratory study
Blood Pressure Usually Considered Normal Is Associated with an Elevated Risk of Cardiovascular Disease
Kshirsagar et al., 2006 · Prospective cohort study
Coronary CT Angiography as a Guide to Timing of Invasive Treatment in Patients With NSTEACS
Kühl et al., 2023 · Expert commentary
A Single-Dose of Oral Nattokinase Potentiates Thrombolysis and Anti-Coagulation Profiles
Kurosawa et al., 2015 · Randomized controlled trial
C-Reactive Protein and Cardiovascular Risk in the General Population
Kurt et al., 2025 · Prospective cohort study
Molecular Basis of Apolipoprotein(a) Isoform Size Heterogeneity as Revealed by Pulsed-Field Gel Electrophoresis
Lackner et al., 1991 · Cross-sectional study
Hyperinsulinemia and the Risk of Cardiovascular Death and Acute Coronary and Cerebrovascular Events in Men
Lakka et al., 2000 · Prospective cohort study
Prevalence of Dyslipidemic Phenotypes in Ischemic Heart Disease
Lamarche et al., 1995 · Prospective cohort study
Apolipoprotein A-I and B Levels and the Risk of Ischemic Heart Disease During a Five-Year Follow-Up
Lamarche et al., 1996 · Prospective cohort study
Small, Dense Low-Density Lipoprotein Particles as a Predictor of the Risk of Ischemic Heart Disease in Men
Lamarche et al., 1997 · Prospective cohort study
Coronary Artery Calcium Score and Coronary Heart Disease Events in a Large Cohort of Asymptomatic Men and Women
LaMonte et al., 2005 · Prospective cohort study
Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD
Lamprea-Montealegre et al., 2020 · Prospective cohort study
Fasting and Nonfasting Lipid Levels and Cardiovascular Risk Prediction
Langsted et al., 2008 · Prospective cohort study
Fasting and Nonfasting Apolipoprotein B-100 and Apolipoprotein A-I and Risk of Ischemic Heart Disease and Total Mortality
Langsted et al., 2011 · Prospective cohort study
Elevated Lipoprotein(a) and Risk of Ischemic Stroke
Langsted et al., 2019 · Prospective cohort study
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease (TNT Trial)
LaRosa et al., 2005 · Randomized controlled trial
Ultra-High-Resolution Coronary CT Angiography for Assessment of Patients with Severe Coronary Artery Calcification
Latina et al., 2021 · Prospective cohort study
Asymptomatic Subjects with Zero Coronary Calcium Score: Coronary CT Angiographic Features of Plaques in Event-Prone Patients
Lee et al., 2013 · Prospective cohort study
Intravascular Imaging-Guided or Angiography-Guided Complex PCI (RENOVATE-COMPLEX-PCI)
Lee et al., 2023 · Randomized controlled trial
Immunoassay of Plasma Low-Density Lipoproteins
Lees, 1970 · Laboratory study
Oxidized Phospholipids Are Present on Plasminogen, Affect Fibrinolysis and Increase Following Acute Myocardial Infarction
Leibundgut et al., 2012 · Translational study
Coronary CT Angiography: Reversal of Earlier Utilization Trends
Levin et al., 2019 · Health services research
Apolipoprotein B Versus LDL-C for Predicting Coronary Heart Disease in Type 2 Diabetes
Li et al., 2021 · Retrospective cohort study
Intravascular Ultrasound-Guided Versus Angiography-Guided PCI in Acute Coronary Syndromes (IVUS-ACS)
Li et al., 2024 · Randomized controlled trial
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT Trial)
Lincoff et al., 2023 · Randomized controlled trial
Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease (LIPID Trial)
LIPID Study Group, 1998 · Randomized controlled trial
Lipid-Lowering, Antihypertensive, and Antithrombotic Effects of Nattokinase Combined with Red Yeast Rice in Stable CAD
Liu et al., 2024 · Randomized controlled trial
National Trends in Statin Use by Coronary Heart Disease Risk Category
Ma et al., 2005 · Cross-sectional analysis
Number of Offspring and Cardiovascular Disease Risk in Men and Women
Magnus et al., 2017 · Prospective cohort study
Detection of Cardiovascular Disease in Elite Athletes Using Cardiac Magnetic Resonance Imaging
Mangold et al., 2013 · Prospective observational study
Effect of the Number of Apolipoprotein(a) Kringle 4 Domains on Immunochemical Measurements of Lipoprotein(a)
Marcovina et al., 1995 · Laboratory study
Use of a Reference Material to Evaluate Analytical Methods for the Determination of Plasma Lipoprotein(a)
Marcovina et al., 2000 · Laboratory study
Initial Invasive or Conservative Strategy for Stable Coronary Disease (ISCHEMIA Trial)
Maron et al., 2020 · Randomized controlled trial
Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction With and Without Atherosclerosis
Marston et al., 2022 · Prospective cohort study
On the Structure of Human Serum Low Density Lipoprotein
Mateu et al., 1972 · In vitro study
Psychological Factors and Their Association with Ideal Cardiovascular Health Among Women and Men
Mathews et al., 2018 · Cross-sectional observational study
Incremental Effects of Eicosapentaenoic Acid on Cardiovascular Events in Statin-Treated Patients with Coronary Artery Disease
Matsuzaki et al., 2009 · Randomized controlled trial
Association of Coronary Heart Disease Risk Factors with Microscopic Qualities of Coronary Atherosclerosis in Youth (PDAY)
McGill et al., 2000 · Autopsy cohort study
cDNA Sequence of Human Apolipoprotein(a) Is Homologous to Plasminogen
McLean et al., 1987 · In vitro study
Lipids, Lipoproteins, and Apolipoproteins as Risk Markers of Myocardial Infarction in 52 Countries (INTERHEART)
McQueen et al., 2008 · Case-control study
Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk
Mehta et al., 2020 · Prospective cohort study
Incomplete source record
Mergen and Sartoretti, 2022 · Unknown
First In-Human Quantitative Plaque Characterization with Ultra-High Resolution Coronary Photon-Counting CT Angiography
Mergen et al., 2022 · Prospective observational study
Coronary Calcium Scans and Radiation Exposure in the Multi-Ethnic Study of Atherosclerosis
Messenger et al., 2016 · Cohort study
Cardiac Device Clinical Trials: Where Are the Women and What Are Their Outcomes?
Minhas and Michos, 2020 · Editorial
Flux Analysis of Cholesterol Biosynthesis In Vivo Reveals Multiple Tissue and Cell-Type Specific Pathways
Mitsche et al., 2015 · Experimental study
Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA)
Miyauchi et al., 2024 · Randomized controlled trial
The Long-Term Prognostic Value Provided by Coronary CT Angiography
Mohammadi and Mohammadi, 2023 · Retrospective cohort study
Lipoprotein Particle Profiles by NMR Compared with Standard Lipids and Apolipoproteins in Predicting Cardiovascular Disease in Women
Mora et al., 2009 · Prospective cohort study
Discordance of LDL Cholesterol with Alternative LDL-Related Measures and Future Coronary Events
Mora et al., 2014 · Prospective cohort study
Discordance Between ApoB and LDL-C: A Cross-Sectional Analysis in a Multi-Ethnic Population
Mora et al., 2018 · Cross-sectional cohort study
Efficacy and Safety of Alirocumab in Statin-Intolerant Patients: Design of ODYSSEY ALTERNATIVE
Moriarty et al., 2014 · Clinical trial design paper
Can We Measure Vulnerable Plaques on Coronary CT Angiography with Both Precision and Accuracy?
Moss and Williams, 2021 · Editorial
Motion-Corrected Whole-Heart PET-MR for Simultaneous Visualisation of Coronary Artery Integrity and Myocardial Viability
Munoz et al., 2018 · Prospective validation study
Effect of EPA/DHA on Coronary High-Intensity Plaques by Noncontrast T1-Weighted Imaging (AQUAMARINE)
Nakao et al., 2024 · Randomized controlled trial
PRECISE Trial: Rationale and Design for a Precision Diagnostic Strategy in Stable Chest Pain
Nanna et al., 2022 · Clinical trial design paper
Fatty Streak Formation in Human Fetal Aortas Is Enhanced by Maternal Hypercholesterolemia
Napoli et al., 1997 · Observational study
Interplay of Coronary Artery Calcification and Traditional Risk Factors for the Prediction of All-Cause Mortality
Nasir et al., 2012 · Prospective cohort study
Polygenic Risk Score Identifies Subgroup with Higher Benefit from Intensive Statin Therapy in WOSCOPS
Natarajan et al., 2017 · Post-hoc analysis of RCT
Patient-Perceived Barriers to Statin Use and High-Intensity Statin Therapy
Navar et al., 2017 · Cross-sectional registry study
Influence of Weight Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Neter et al., 2003 · Meta-analysis
Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients (GLAGOV Trial)
Nicholls et al. (GLAGOV), 2016 · Randomized controlled trial
Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events (STRENGTH)
Nicholls et al. (STRENGTH), 2020 · Randomized controlled trial
Effect of Two Intensive Statin Regimens on Progression of Coronary Disease (SATURN Trial)
Nicholls et al., 2011 · Randomized controlled trial
Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients with NSTEMI
Nicholls et al., 2022 · Randomized controlled trial
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients (CLEAR Outcomes)
Nicholls et al., 2024 · Randomized controlled trial
Rationale and Design of the RESPECT-EPA Trial
Nishizaki et al., 2023 · Clinical trial design paper
Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis (ASTEROID Trial)
Nissen et al. (ASTEROID), 2006 · Single-arm prospective study
Effect of Intensive Compared with Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis (REVERSAL Trial)
Nissen et al., 2004 · Randomized controlled trial
Lipoprotein(a) Levels in a Global Patient Population with Established ASCVD (Lp(a)HERITAGE)
Nissen et al., 2022 · Cross-sectional study
Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women
Nordestgaard et al., 2007 · Prospective cohort study
Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk: Insights from FOURIER
O'Donoghue et al., 2019 · Post-hoc analysis of RCT
Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk: Insights from FOURIER
O'Donoghue et al., 2019 · Post-hoc analysis of RCT
Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease (OCEAN(a)-DOSE)
O'Donoghue et al., 2022 · Phase 2 randomized controlled trial
IVUS versus Angiographic-Guided PCI in Long Coronary Lesions (TULIP Trial)
Oemrawsingh et al., 2002 · Randomized controlled trial
Multiparity and Ideal Cardiovascular Health Among Women in the MESA Study
Ogunmoroti et al., 2019 · Cross-sectional study
High-Resolution Late Gadolinium Enhancement Cardiac MRI: Feasibility Study
Ohta et al., 2022 · Feasibility study
Gender Differences in Patient-Reported Outcomes Among Adults with Established Cardiovascular Disease
Okunrintemi et al., 2018 · Cross-sectional study
The SYNTAX Score: A Grading System for Complex Coronary Artery Disease
Ong et al., 2006 · Clinical trial design paper
Low-Density Lipoprotein and High-Density Lipoprotein Particle Subclasses Predict Coronary Events and Are Favorably Changed by Gemfibrozil Therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
Otvos et al., 2011 · Prospective cohort study
Sex and Race Differences in HDL-C in Patients with Acute Coronary Syndrome
Ozaki et al., 2021 · Retrospective observational study
IVUS-Guided Versus Angiography-Guided Left Main Coronary Artery Stenting
Park et al., 2009 · Observational cohort study
Coronary Artery Calcium for Major Adverse Cardiovascular Event Prediction (SILICAS Study)
Parma et al., 2016 · Prospective observational study
Lp(a) Concentrations and Incident Atherosclerotic Cardiovascular Disease: New Insights From a Large National Biobank
Patel et al., 2021 · Prospective cohort study
Impact of SPECT MPI, PET MPI, CCTA and Stress Echo on Downstream Healthcare Utilization in CAD
Pelletier-Galarneau et al., 2024 · Retrospective comparative study
EPA and DHA Supplementation Increases HDL Content in n-3 Fatty Acids and Improves Endothelial Function in Hypertriglyceridemic Patients
Peña-de-la-Sancha et al., 2023 · Controlled clinical trial
Apolipoprotein B Improves Risk Assessment Beyond LDL-C and Non-HDL-C in the Framingham Heart Study
Pencina et al., 2015 · Prospective cohort study
The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies
Pepin & Gupta, 2024 · Narrative review
Accuracy of Low-Dose CT Angiography for In-Stent Restenosis Assessment in Iliac Arteries
Perisinakis et al., 2011 · Phantom study
Nattospes as Effective and Safe Functional Supplements in Management of Stroke
Pham et al., 2020 · Randomized controlled trial
Non-HDL Cholesterol and Apolipoprotein B in the Prediction of Coronary Heart Disease in Men
Pischon et al., 2005 · Prospective nested case-control study
Systemic Inflammation Predicts All-Cause Mortality: A Glasgow Inflammation Outcome Study
Proctor et al., 2015 · Prospective cohort study
Age-Specific Relevance of Usual Blood Pressure to Vascular Mortality: A Meta-Analysis of 1 Million Adults
Prospective Studies Collaboration, 2002 · Meta-analysis
High-Resolution Cardiac MRI for Identification of Coronary Microvascular Dysfunction
Rahman et al., 2021 · Prospective observational study
Re-evaluation of the Traditional Diet-Heart Hypothesis: Minnesota Coronary Experiment Reanalysis
Ramsden et al., 2016 · Randomized controlled trial reanalysis
Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol (CLEAR Harmony)
Ray et al., 2019 · Randomized controlled trial
Inclisiran in Patients with Elevated LDL Cholesterol
Ray et al., 2020 · Randomized controlled trial
Lipoprotein(a) and Risk-Weighted Apolipoprotein B: A Novel Metric for Atherogenic Risk
Rehman and Tudrej, 2024 · Methodology/validation study
EPA Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation
Reiner et al., 2021 · Cross-sectional observational study
On the Way to Routine Cardiac MRI at 7 Tesla: A Pilot Study of 84 Examinations
Reiter et al., 2021 · Pilot study
Clinical Study on the Effect of Nattokinase on Carotid Artery Atherosclerosis and Hyperlipidemia
Ren et al., 2017 · Randomized controlled trial
Outcomes in the ISCHEMIA Trial Based on CAD and Ischemia Severity
Reynolds et al., 2021 · Post-hoc subgroup analysis
Representation of Women Authors in International Heart Failure Guidelines and Clinical Trials
Reza et al., 2020 · Observational analysis
ApoB Is the Fundamental Driver of Atherogenic Risk: A Multivariable Mendelian Randomization Analysis
Richardson et al., 2020 · Mendelian randomization study
Non-HDL Cholesterol, ApoB, Standard Lipid Measures, and CRP as Risk Factors for Cardiovascular Disease in Women
Ridker et al., 2005 · Prospective cohort study
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein (JUPITER)
Ridker et al., 2008 · Randomized controlled trial
Reduction in CRP and LDL-C and Cardiovascular Event Rates After Initiation of Rosuvastatin (JUPITER)
Ridker et al., 2009 · Prospective analysis of randomized trial
HDL Cholesterol and Residual Risk After Potent Statin Therapy: A JUPITER Analysis
Ridker et al., 2010 · Prespecified analysis of randomized trial
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease (CANTOS)
Ridker et al., 2017 · Randomized controlled trial
Relationship of LDL-C and Lp(a) to Cardiovascular Risk in MESA
Rikhi et al., 2022 · Prospective cohort study
Meta-Analysis Comparing Effectiveness of Lowering ApoB vs LDL-C and Non-HDL-C for Cardiovascular Risk Reduction
Robinson et al., 2012 · Meta-analysis
Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events (ODYSSEY LONG TERM)
Robinson et al., 2015 · Randomized controlled trial
Correction of Respiratory and Cardiac Motion in Cardiac PET/MR Using MR-Based Motion Modeling
Robson et al., 2018 · Proof-of-concept study
Lipoprotein Apheresis for Lp(a)-Associated Cardiovascular Disease: 5-Year Prospective Follow-Up (Pro(a)LiFe)
Roeseler et al., 2016 · Prospective observational cohort study
Lipoprotein(a) Integrates Monocyte-Mediated Thrombosis and Inflammation in Atherosclerotic Cardiovascular Disease
Rosenson et al., 2025 · Translational study
Long-Term Weight Loss Effects of Semaglutide in Obesity Without Diabetes in the SELECT Trial
Ryan et al., 2024 · Prespecified analysis of randomized trial
Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events (OSLER)
Sabatine et al., 2015 · Open-label randomized trial
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease (FOURIER Trial)
Sabatine et al., 2017 · Randomized controlled trial
Effect of Pravastatin on Coronary Events After Myocardial Infarction in Patients with Average Cholesterol Levels (CARE Trial)
Sacks et al., 1996 · Randomized controlled trial
Effect of a Mediterranean Diet Supplemented with Nuts on Metabolic Syndrome Status (PREDIMED)
Salas-Salvadó et al., 2008 · Randomized controlled trial
Association of HDL Cholesterol Efflux Capacity with Incident Coronary Heart Disease Events
Saleheen et al., 2015 · Prospective nested case-control study
Reduced Plasma Desmosterol-to-Cholesterol Ratio and Longitudinal Cognitive Decline in Alzheimer's Disease
Sato et al., 2015 · Cohort study
Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Regression of Atherosclerosis
Savarese et al., 2015 · Meta-analysis
Individual Variation in ApoB Levels Across the Spectrum of LDL-C or Non-HDL-C Levels
Sayed et al., 2024 · Cross-sectional study
Randomised Trial of Cholesterol Lowering in 4444 Patients with Coronary Heart Disease: The 4S Trial
Scandinavian Simvastatin Survival Study Group, 1994 · Randomized controlled trial
Cholesterol-Year Score and Severity of Calcific Atherosclerosis in Homozygous Familial Hypercholesterolemia
Schmidt et al., 1996 · Observational cohort study
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome (ODYSSEY Outcomes)
Schwartz et al., 2018 · Randomized controlled trial
ApoB, LDL-C, and Non-HDL-C as Markers of Cardiovascular Risk: A Systematic Review of Discordance Analyses
Sehayek et al., 2025 · Systematic review
Lipoprotein Insulin Resistance Index: A Lipoprotein Particle-Derived Measure of Insulin Resistance
Shalaurova et al., 2014 · Observational validation study
Pravastatin in Elderly Individuals at Risk of Vascular Disease (PROSPER)
Shepherd et al., 2002 · Randomized controlled trial
Coronary CT Angiography with Photon-Counting CT: First-In-Human Results
Si-Mohamed et al., 2022 · Prospective comparative study
Repeating Patterns of Sleep Restriction and Recovery: Do We Get Used to It?
Simpson et al., 2016 · Randomized crossover study
Diagnostic Value of Cardiac MRI in the Evaluation of Arrhythmia and Cardiomyopathy
Singh et al., 2024 · Prospective observational study
Sudden Cardiac Death as First Manifestation of Cardiovascular Disease: A Nationwide Study of 54,028 Deaths
Skjelbred et al., 2025 · Nationwide population study
Photon-Counting CT vs Energy-Integrating CT for Coronary CT Angiography: Image Quality Comparison
Skoog et al., 2023 · Prospective observational study
Trends in PCSK9 Inhibitor Use After Price Reduction: A Real-World Analysis
Smith et al., 2021 · Retrospective cohort study
ApoB in Clinical Practice: Pro/Con Debate on Its Role as a Routine Lipid Marker
Sniderman and Robinson, 2019 · Debate article
Association of Coronary Atherosclerosis with Hyperapobetalipoproteinemia: Normal Cholesterol but Elevated ApoB
Sniderman et al., 1980 · Cross-sectional study
Concordance and Discordance Between ApoB and LDL-C in a Population with Mixed Hyperlipidemia
Sniderman et al., 2003 · Cross-sectional analysis
A Meta-Analysis and Systematic Review of the Relative Efficacy and Safety of Treatment With Statins for Assessing Cardiovascular Risk: Comparing ApoB, Non-HDL-C, and LDL-C
Sniderman et al., 2011 · Meta-analysis
ApoB and Non-HDL Cholesterol as Discordant Predictors of Coronary Artery Disease: INTERHEART Secondary Analysis
Sniderman et al., 2012 · Secondary analysis of cross-sectional case-control study
Applying ApoB to Clinical Practice: A Critique of Current Arguments Against Its Routine Use
Sniderman, 2007 · Commentary
The ApoB Blind Spot: How ACC/AHA Guidelines Underemphasize the Most Important Lipid Risk Marker
Sniderman, 2019 · Editorial
Apolipoprotein B: A Physiologic Argument for Its Use in Cardiovascular Disease Prevention
Sniderman, Pencina, and Thanassoulis, 2019 · Editorial
Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial
SPRINT MIND Investigators, 2019 · Randomized controlled trial
A Randomized Trial of Intensive versus Standard Blood-Pressure Control (SPRINT)
SPRINT Research Group, 2015 · Randomized controlled trial
Fasting and Nonfasting Lipids in Pediatric Patients: Implications for Universal Lipid Screening
Steiner et al., 2011 · Cross-sectional study
Potent Lp(a) Lowering Following Evolocumab Is Associated With Reduction in Arterial Wall Inflammation
Stiekema et al., 2018 · Randomized controlled trial
PROTECTION VI: Worldwide Dose Survey of Cardiac CT in Clinical Practice
Stocker et al., 2018 · Prospective multicenter registry
A Prospective Natural-History Study of Coronary Atherosclerosis (PROSPECT)
Stone et al., 2011 · Prospective cohort study
Sex Hormones and Coronary Artery Calcium Progression in Postmenopausal Women: MESA
Subramanya et al., 2018 · Prospective cohort study
A Novel Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto: A Typical Soybean Food Made from Fermented Soybeans
Sumi et al., 1987 · Basic science study
Dual-Source CT Angiography: Radiation Dose Optimization Using Phantom Study
Sun and Ng, 2010 · Phantom study
Dietary Supplementation of Fermented Soybean, Natto, Suppresses Intimal Thickening and Modulates the Lysis of Mural Thrombi After Endothelial Injury in Rat Femoral Artery
Suzuki et al., 2003 · Animal study
Lp(a) Lowering by Alirocumab Reduces the Total Burden of Cardiovascular Events: ODYSSEY OUTCOMES
Szarek et al., 2020 · Post-hoc analysis of randomized controlled trial
Lipoprotein(a) and Non-Lp(a) ApoB: Differential Atherogenicity per Particle in the ODYSSEY OUTCOMES Trial
Szarek et al., 2023 · Post-hoc analysis of randomized controlled trial
Ultra-High-Resolution CT for Coronary CT Angiography vs Invasive Coronary Angiography
Takagi et al., 2018 · Observational study
The EPA/AA Ratio as a Residual Risk Marker in Statin-Treated Coronary Artery Disease Patients
Tani et al., 2017 · Randomized controlled trial
EPA Supplementation and HDL Particle Heterogeneity in Statin-Treated Coronary Artery Disease Patients
Tani et al., 2020 · Randomized controlled trial
Natto and Viscous Vegetables in a Japanese-Style Breakfast Improved Insulin Sensitivity, Lipid Metabolism and Oxidative Stress in Overweight Subjects with Impaired Glucose Tolerance
Taniguchi-Fukatsu et al., 2012 · Randomized crossover trial
Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction (COLCOT)
Tardif et al., 2019 · Randomized controlled trial
Pharmacogenomics-Guided Dalcetrapib Therapy after an Acute Coronary Syndrome (dal-GenE)
Tardif et al., 2022 · Randomized controlled trial
Genetic Associations with Valvular Calcification and Aortic Stenosis: The CHARGE Consortium
Thanassoulis et al., 2013 · Genome-wide association study
ApoB vs Non-HDL-C vs LDL-C as Predictors of Statin Benefit: A Meta-Analysis
Thanassoulis et al., 2014 · Meta-analysis
A Benefit-Based Approach to Cholesterol-Lowering Prevention: A Proposal for Guideline-Friendly Individualization
Thanassoulis et al., 2017 · Commentary
Efficacy of Statins for Primary Prevention in People at Low Cardiovascular Risk: A Meta-Analysis
Tonelli et al., 2011 · Meta-analysis
Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention (FAME)
Tonino et al., 2009 · Randomized controlled trial
ApoB vs LDL-P Discordance and Insulin Resistance: Analysis of a Large Clinical Population
Toth et al., 2015 · Cross-sectional study
ApoB Discordance with LDL-C and Coronary Artery Calcium in the Multi-Ethnic Study of Atherosclerosis
Tsai et al., 2019 · Prospective cohort study
Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease
Tsimikas et al., 2005 · Cross-sectional study
Relationship of Oxidation-Specific Biomarkers, Lipoprotein(a), and Apolipoprotein(a) Isoforms with Coronary Heart Disease
Tsimikas et al., 2010 · Prospective nested case-control study
Safety and Efficacy of an Antisense Oligonucleotide to Apo(a) in Patients with Elevated Lp(a): ISIS-APO(a)Rx Phase 1 Trial
Tsimikas et al., 2015 · Phase 1 randomized clinical trial
Pelacarsen (TQJ230/APO(a)-LRx) for Lp(a) Lowering: Phase 2 Randomized Trial
Tsimikas et al., 2020 · Phase 2 randomized controlled trial
Impact of Dual Lipid-Lowering Strategy with Pitavastatin and Ezetimibe on Coronary Plaque Regression (PRECISE-IVUS)
Tsujita et al., 2015 · Randomized controlled trial
Intake of Fermented Soybean (Natto) Increases Circulating Vitamin K2 and Osteocalcin in Elderly Japanese Women
Tsukamoto et al., 2000 · Clinical trial
Deep Learning for Cardiac MRI Segmentation and Registration
Upendra et al., 2021 · Technical development study
Profibrinolytic Activity of Nattokinase (Subtilisin NAT): Cleavage of Plasminogen Activator Inhibitor Type 1
Urano et al., 2001 · Basic science study
Polymorphism of Apolipoprotein(a): Lp(a) Concentration and Isoform Sizes in a Healthy Population
Utermann et al., 1987 · Case series
Coronary Artery Calcium Scoring and Long-Term Mortality in Asymptomatic Hypertensive Patients
Valenti et al., 2015 · Prospective cohort study
OxPL on Lp(a) Elicits Arterial Wall Inflammation and Monocyte Trafficking via LOX-1
van der Valk et al., 2016 · Translational study
Sleep Restriction Increases the Risk of Developing Cardiovascular Diseases by Augmenting Proinflammatory Responses via IL-17 and CRP
van Leeuwen et al., 2009 · Randomized controlled trial
CAD-RADS 2.0 and CTA-Based Risk Stratification for Long-Term MACE Prediction: C-CORE Registry
van Rosendael et al., 2023 · Prospective registry study
Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease: A Mendelian Randomization Study
Varbo et al., 2013 · Mendelian randomization study
Accuracy of Noncontrast QISS MR Angiography Versus CT Angiography for Peripheral Artery Disease
Varga-Szemes et al., 2017 · Comparative diagnostic study
Antisense Oligonucleotides Targeting Apolipoprotein(a) in People with Raised Lipoprotein(a): Two Dose-Ranging Trials
Viney et al., 2016 · Randomized controlled trial
Plasma HDL Cholesterol and Risk of Myocardial Infarction: A Mendelian Randomisation Study
Voight et al., 2012 · Mendelian randomization study
Apolipoprotein B Identifies Dyslipidemic Phenotypes in Normocholesterolemic Type 2 Diabetic Patients
Wagner et al., 1999 · Cross-sectional clinical study
High ApoB, Low ApoA-I, and the ApoB/ApoA-I Ratio as Predictors of Fatal Myocardial Infarction: The AMORIS Study
Walldius et al., 2001 · Prospective cohort study
Stroke Mortality and the ApoB/ApoA-I Ratio: Results from the AMORIS Prospective Study
Walldius et al., 2006 · Prospective cohort study
Long-Term Risk of Major Cardiovascular Events by ApoB, ApoA-1, and the ApoB/ApoA-1 Ratio: The Swedish AMORIS Cohort
Walldius et al., 2021 · Prospective cohort study
Nattokinase Reduces Brain Infarction and Coagulation Parameters in Gerbil Cerebral Ischemia-Reperfusion
Wang et al., 2012 · Animal study
Risk Factors and Outcomes of Heart Failure Following First-Episode Acute Myocardial Infarction: 161,384 Cases
Wang et al., 2021 · Retrospective cohort study
Compounding Benefits of Cholesterol-Lowering Therapy for Major Cardiovascular Events: Systematic Review and Meta-Analysis
Wang et al., 2022 · Systematic review and meta-analysis
A Randomized Controlled Trial of Eicosapentaenoic Acid in Patients With Coronary Heart Disease on Statins: The CHERRY Study
Watanabe et al., 2017 · Randomized controlled trial
Comparison of Conventional Lipoprotein Tests and Apolipoproteins in the Prediction of Cardiovascular Disease: UK Biobank
Welsh et al., 2019 · Prospective cohort study
Coronary Fatty Plaque Regression and Cardiac Events with EPA and DHA by Blood Pressure Status
Welty et al., 2023 · Randomized controlled trial
Machine Learning-Based CAC Score Prediction from Clinical Variables as a Prognostic Indicator
Wen et al., 2024 · Retrospective cohort study
WOSCOPS: Identification of High-Risk Groups and Comparison with Other Cardiovascular Intervention Trials
West of Scotland, 1996 · Subgroup analysis
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Women's Health Initiative
WHI, 2002 · Randomized controlled trial
ApoB-LDL-C Discordance in Young Adults Predicts Coronary Artery Calcification at Midlife: CARDIA
Wilkins et al., 2016 · Prospective cohort study
Lp(a) Discrimination and Risk Reclassification: Prospective 15-Year Outcomes in the Bruneck Study
Willeit et al., 2014 · Prospective cohort study
Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial
Williamson et al., 2019 · Randomized controlled trial
Aortoiliac and Lower Extremity Arteries Assessed with 16-Detector Row CT Angiography vs Digital Subtraction Angiography
Willmann et al., 2005 · Prospective comparative study
Risk Factors and Progression of Atherosclerosis in Youth: PDAY Study
Wissler and Strong, 1998 · Autopsy study
IVUS Guidance and Clinical Outcomes After Drug-Eluting Stents: The ADAPT-DES Study
Witzenbichler et al., 2013 · Prospective cohort study
Lipoprotein(a) and Long-Term Cardiovascular Risk in a Multi-Ethnic Pooled Prospective Cohort
Wong et al., 2024 · Pooled prospective cohort study
Noncontrast QISS MRA at 3T vs CT Angiography for Lower Extremity Peripheral Arterial Disease
Wu et al., 2016 · Comparative diagnostic study
Nattokinase Breaks the Vicious Loop Between Inflammation, Oxidative Stress, and Coagulation via LPS-Induced Macrophage Signaling
Wu et al., 2020 · Experimental study
Simultaneous CT Angiography of Lower Extremity and Coronary Arteries Using 256-Slice CT: Feasibility Study
Xie et al., 2015 · Feasibility study
Thrombolytic Effects of Nattokinase In Vivo in a Carrageenan-Induced Rat Thrombosis Model
Xu et al., 2014 · Animal study
Landmark Detection in Cardiac MRI by Convolutional Neural Network
Xue et al., 2021 · Technical development study
Nattokinase-Promoted tPA Release From Human Cells: Indirect Fibrinolytic Mechanism
Yatagai et al., 2008 · In vitro study
Prevalence of Coronary Artery Disease in Symptomatic Patients with Zero CAC Score by Age Group
Yu et al., 2021 · Cross-sectional study
Effect of Potentially Modifiable Risk Factors Associated with Myocardial Infarction in 52 Countries: The INTERHEART Study
Yusuf et al. (INTERHEART), 2004 · Case-control study
Molecular Interactions Between Nattokinase and Heparin/Glycosaminoglycans
Zhang et al., 2015 · In vitro biochemical study
Race and Sex Differences in Silent Myocardial Infarction Incidence and Prognosis: ARIC Study
Zhang et al., 2016 · Prospective cohort study
IVUS Versus Angiography-Guided Drug-Eluting Stent Implantation: The ULTIMATE Trial
Zhang et al., 2018 · Randomized controlled trial
N-Acetyl Cysteine Protects Vascular Endothelial Cells Against LPS-Induced Inflammation via NF-κB Pathway
Zhang et al., 2019 · In vitro study
Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension (STEP)
Zhang et al., 2021 · Randomized controlled trial
Endogenous Sex Hormones and Incident Cardiovascular Disease in Postmenopausal Women: MESA
Zhao et al., 2018 · Prospective cohort study
Multivariable Mendelian Randomization Prioritizes ApoB as Key Lipid Risk Factor for Coronary Artery Disease
Zuber et al., 2021 · Mendelian randomization study