Functional Outcome After Revascularization in Chronic Ischemic Heart Disease: A Late Gadolinium Enhancement CMR Study
Olga Bondarenko, Aernout M Beek, Albert C van Rossum · Prospective imaging study
BlueRipple Assessment
Before sending a patient with a weakened heart for revascularization, the key question is whether the muscle can actually recover. Cardiac MRI with late gadolinium enhancement images scar tissue directly, and this study refined how to read it for that prediction.
In 45 patients, the investigators tested whether adding measures of viable rim thickness and procedure-related muscle injury improved the standard MRI predictor of recovery. The main finding held to the established rule: heart segments with more than 75 percent scar did not regain function. Periprocedural necrosis — damage from the procedure itself — was the only negative predictor of improvement, while the extra measure of viable rim thickness added nothing useful.
This is a small, specialized imaging study. Its contribution is incremental and technical: confirming that transmural scar extent on MRI is the workhorse predictor of functional recovery and that some proposed refinements do not earn their keep.
We rate the evidence moderate-to-limited. The sample is small and the endpoint is a physiological surrogate, but the work is sound and reinforces how MRI guides decisions about whether revascularization will help a damaged heart.
The original source
Bondarenko O, Beek AM, Nijveldt R, McCann GP, van Dockum WG, Hofman MBM, Twisk JWR, Visser CA, van Rossum AC. Functional outcome after revascularization in patients with chronic ischemic heart disease: a quantitative late gadolinium enhancement CMR study evaluating transmural scar extent, wall thickness and periprocedural necrosis. J Cardiovasc Magn Reson. 2007;9(5):815-21.
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