Understanding Cardiac MRI Results and What They Mean

Introduction

Receiving cardiac MRI results can be overwhelming. Reports contain unfamiliar terminology, numerical measurements, and assessments of findings that require clinical context to interpret. Understanding what constitutes normal values, what various abnormalities signify, and how findings integrate with other information helps patients participate meaningfully in discussions with their cardiologists.

This article translates cardiac MRI reports into understandable terms. It covers normal reference ranges, explains how age and sex affect interpretation, describes patterns that distinguish different heart conditions, and identifies common misinterpretations. The goal is informed patient engagement rather than self-diagnosis.

Interpreting cardiac MRI results requires understanding how the test works and recognizing the technical factors that affect quality. Results should prompt discussion about how findings change treatment and when follow-up imaging is appropriate.

What is a normal cardiac MRI report and what values indicate healthy heart function?

A normal cardiac MRI report describes chambers of appropriate size and wall thickness, normal contractile function, no evidence of scar or abnormal tissue, and structurally normal valves. Quantitative measurements should fall within published reference ranges, though these ranges vary by age, sex, and body size. The report should explicitly state whether findings are normal or abnormal.

Left ventricular ejection fraction, the most commonly referenced measurement, normally ranges from 55-70% in healthy adults. Values below 50% indicate systolic dysfunction, with severity grades of mild (40-49%), moderate (30-39%), and severe (below 30%). End-diastolic volume normalized to body surface area should be 62-96 mL/m² for men and 53-77 mL/m² for women.

Absence of late gadolinium enhancement indicates no detectable myocardial scar, a reassuring finding in patients being evaluated for suspected coronary disease or cardiomyopathy. Normal native T1 and T2 values suggest no diffuse fibrosis or edema. Comprehensive normal values exist for all quantitative cardiac MRI parameters (Kolentinis et al., 2020).

How do cardiac MRI reference ranges differ by age, sex, and body size?

Published reference ranges account for known biological variation across demographics. Men have larger absolute ventricular volumes than women due to body size differences. Indexing volumes to body surface area partially corrects this, but sex-specific ranges remain necessary for accurate classification. Heart size also increases modestly with age in healthy adults.

Ejection fraction shows minimal variation with age or sex in healthy populations. However, wall thickness references differ importantly between sexes, with men normally having slightly thicker walls. Applying male reference ranges to female patients could miss concentric hypertrophy. Similarly, applying adult values to adolescents produces erroneous conclusions.

Ethnicity may also affect normal values, though less well characterized than age and sex effects. Some studies suggest African ancestry is associated with modestly higher left ventricular mass. Current reference ranges derive primarily from European and North American populations (Klemenz et al., 2024). Interpreters should recognize these limitations when evaluating diverse patients.

What does it mean when a cardiac MRI shows “scar” or “fibrosis” in the heart muscle?

Scar or fibrosis on cardiac MRI represents areas where normal heart muscle has been replaced by non-contractile connective tissue. This tissue retains gadolinium contrast longer than healthy myocardium, creating the bright signal on late enhancement images. The presence of scar indicates prior injury, though the timing of that injury cannot always be determined from imaging alone.

Scar reduces contractile function proportionally to its extent. Small areas of focal scar may not affect overall ejection fraction noticeably. Larger scar burdens or strategically located scars cause measurable dysfunction. Transmural extent predicts whether segments will recover function with revascularization (Kim et al., 2000). Segments with more than 50% transmural scar rarely improve even with successful coronary intervention.

Scar also creates substrate for dangerous arrhythmias. Electrical conduction around scar borders can form reentrant circuits causing ventricular tachycardia. Scar burden and pattern factor into risk stratification for sudden cardiac death and defibrillator implantation decisions (Sawlani and Collins, 2016).

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How does the pattern of late gadolinium enhancement help distinguish between different causes of heart disease?

Ischemic injury from coronary artery disease produces enhancement beginning at the endocardial surface, where tissue is most vulnerable to oxygen deprivation. Enhancement respects coronary artery distributions. A subendocardial or transmural scar in the anterior wall suggests left anterior descending artery disease. Inferior wall involvement implicates the right coronary artery.

Non-ischemic patterns differ characteristically. Dilated cardiomyopathy, when enhancement is present, shows mid-wall linear streaks rather than subendocardial involvement. Hypertrophic cardiomyopathy produces patchy enhancement at sites of maximal hypertrophy and right ventricular insertion points. Myocarditis creates epicardial or mid-wall enhancement sparing the subendocardium (Singh et al., 2024).

Infiltrative diseases have distinctive appearances. Cardiac amyloidosis causes diffuse subendocardial enhancement with difficulty nulling myocardium due to expanded extracellular space. Sarcoidosis produces patchy mid-wall or epicardial enhancement often involving the basal septum. These patterns provide diagnostic specificity that often eliminates the need for tissue biopsy (Al-Sabeq et al., 2019).

What findings on cardiac MRI suggest ischemic heart disease versus non-ischemic cardiomyopathy?

The distinction between ischemic and non-ischemic causes of heart failure fundamentally affects treatment. Ischemic cardiomyopathy results from coronary artery disease and may benefit from revascularization. Non-ischemic cardiomyopathies require different management strategies. Cardiac MRI provides tissue-level information that helps make this distinction.

Classic ischemic findings include subendocardial or transmural late enhancement in a coronary distribution, regional wall motion abnormalities matching enhancement patterns, and possible stress-induced perfusion deficits in viable territories. The combination of scar in a coronary distribution with reduced function strongly supports ischemic etiology (Kwong and Korlakunta, 2008).

Non-ischemic cardiomyopathy features include global hypokinesis without regional predominance, mid-wall or epicardial enhancement not respecting coronary distributions, and absence of perfusion abnormalities on stress testing. However, mixed presentations occur. Patients may have both coronary disease and non-ischemic cardiomyopathy. Cardiac MRI findings require integration with coronary imaging and clinical context.

What does cardiac MRI reveal about heart valve function and how accurate is it compared to echocardiography?

Cardiac MRI quantifies regurgitant volumes by measuring flow directly in the great vessels. Phase contrast imaging determines the volume of blood flowing forward through the aorta and backward through a regurgitant valve. This direct flow quantification is more reproducible than echocardiographic estimates based on color Doppler jet characteristics.

Valve morphology assessment favors echocardiography for most applications. Real-time imaging at high temporal resolution visualizes leaflet motion better than standard cardiac MRI sequences. Vegetations, small perforations, and subtle prolapse may be more apparent on echo. Cardiac MRI adds value when echocardiographic windows are poor or discordant with clinical assessment.

For regurgitation quantification specifically, cardiac MRI serves as the reference standard (Poon et al., 2002). Guidelines incorporate cardiac MRI for grading aortic and mitral regurgitation when echocardiographic assessment is inconclusive. The technique is particularly valuable for tricuspid and pulmonic valve quantification, where echocardiography is less reliable.

How should patients interpret “incidental findings” that appear on cardiac MRI?

Cardiac MRI images include portions of the lungs, liver, spine, and other adjacent structures. Abnormalities in these areas unrelated to the clinical question occasionally appear. Some incidental findings require follow-up or additional evaluation. Others are clinically insignificant variants requiring only notation.

Common incidental findings include simple renal cysts, hepatic hemangiomas, thyroid nodules, and spinal degenerative changes. Most of these represent benign conditions with no clinical consequence. Reports typically note these findings and recommend follow-up only when potentially significant. Patients should not panic about mentioned incidentalomas without discussing implications with their physicians.

Potentially significant incidental findings include pulmonary nodules, solid organ masses, and vascular abnormalities. These require appropriate follow-up imaging or subspecialty evaluation. The referring physician should communicate these findings and ensure proper follow-through. Patients can ask specifically whether any incidental findings need attention beyond the primary cardiac question.

What are common misinterpretations or overcalls on cardiac MRI that patients should be aware of?

Artifact mimicking pathology represents a significant interpretation challenge. Susceptibility artifacts from nearby devices can resemble thrombus or tumor. Flow artifacts may simulate regurgitant jets. Motion artifact creates apparent wall motion abnormalities. Experienced interpreters recognize these technical mimics (Rafiee et al., 2024).

Normal variants occasionally raise concern. Mild apical thinning occurs normally and should not be called aneurysm without functional confirmation. Septal contributions from right ventricular moderator bands may be misidentified as abnormal masses. Fatty infiltration of the right ventricular free wall can represent a normal variant rather than arrhythmogenic cardiomyopathy.

Quantitative thresholds drive some overcalls. Ejection fraction of 53% technically falls below normal range but may not represent clinically significant dysfunction. Trivial enhancement at the right ventricular insertion points occurs commonly and may not indicate pathology. Patients with borderline findings should discuss clinical significance rather than assuming all abnormalities require intervention.

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When cardiac MRI findings are ambiguous, what determines whether additional testing is needed?

Clinical context determines how aggressively to pursue ambiguous findings. A young athlete with screening abnormality requires definitive characterization to clear for competition. An elderly patient with multiple comorbidities and uncertain enhancement may reasonably be monitored clinically. The consequences of missing or overdiagnosing pathology inform the testing threshold.

Technical adequacy affects interpretation confidence. Ambiguity arising from suboptimal image quality may resolve with repeat imaging using optimized technique or different scanner. Ambiguity persisting despite excellent technical quality reflects genuine diagnostic uncertainty. Consider whether additional MRI sequences not included in the original protocol might resolve the question.

Alternative modalities may provide complementary information. Echocardiography offers real-time assessment and different tissue characterization. Cardiac CT provides superior coronary visualization. Nuclear imaging assesses perfusion differently. Invasive testing including catheterization or biopsy may be needed when noninvasive approaches remain inconclusive (Morton et al., 2010).

How do cardiologists integrate cardiac MRI findings with other test results to form a diagnosis?

Cardiac MRI rarely exists in isolation. Patients typically have prior electrocardiograms, echocardiograms, laboratory values, and clinical assessments. Integration requires weighing the strengths and limitations of each information source. Cardiac MRI’s tissue characterization capabilities add dimensions unavailable from other testing.

Discordance between tests requires explanation rather than dismissal. When echocardiography suggests normal function and cardiac MRI shows reduced ejection fraction, technical factors for each test should be evaluated. When CT shows moderate stenosis and cardiac MRI shows no ischemia, the physiologic significance of anatomical findings must be considered.

Clinical correlation ultimately determines diagnosis. Cardiac MRI findings must fit coherently with patient symptoms, examination findings, and disease trajectory. A pattern classic for one condition in a patient whose presentation suggests another requires reconciliation. Diagnostic confidence grows when multiple independent information sources converge on consistent conclusions.

Conclusion

Cardiac MRI reports contain complex information requiring clinical context for proper interpretation. Normal values vary by demographics. Scar patterns distinguish between different disease etiologies. Quantitative measurements have inherent variability that should temper interpretation of borderline values. Artifacts and normal variants can mimic pathology.

Patients benefit from reviewing results with their cardiologists rather than interpreting reports independently. Understanding what findings mean and do not mean enables productive conversations about implications and next steps. Reports should inform rather than replace clinical judgment.

The next article examines how cardiac MRI compares to alternative imaging modalities, helping patients understand when each test adds value. Subsequent articles address how findings translate into treatment decisions and serial monitoring approaches.