How to Interpret Your CAC Score

Introduction

A CAC scan produces a number. Knowing what that number means requires context. The same score carries different implications for a 45-year-old woman than for a 70-year-old man. Percentile rankings adjust for these demographic differences, but raw scores still drive clinical decision-making about medication and lifestyle intensity.

CAC interpretation also requires understanding what the scan cannot tell you. The presence of calcium confirms atherosclerosis but does not reveal how much the artery has narrowed. A score of zero dramatically reduces your short-term risk but does not exclude soft plaque that the scan cannot detect. These nuances matter for translating a test result into a treatment plan.

This article explains the standard CAC score categories, how percentiles provide age and sex context, the relationship between calcium and obstruction, and what happens when someone with a zero score still develops heart disease. For guidance on next steps after receiving your results, see What to Do With Your CAC Results.

What do the standard CAC score categories indicate?

Clinical practice groups CAC scores into ranges that correspond to increasing levels of atherosclerotic burden and cardiovascular risk. A score of zero indicates no detectable calcified plaque. Scores of 1-99 represent mild calcification. Scores of 100-399 indicate moderate disease. Scores of 400 or higher signal extensive calcification.

The CAC Consortium analyzed over 66,000 patients and found that cardiovascular mortality increases progressively across these categories. Compared to a score of zero, a score of 100-399 carried roughly three times the mortality risk, while scores above 1,000 carried more than six times the risk over a median follow-up of 12 years (Grandhi, 2020).

These thresholds emerged from observational data rather than biological cutoffs. Someone with a score of 99 is not meaningfully different from someone with 101. But the categories help clinicians and patients communicate about risk levels and frame treatment decisions. Guidelines often reference the 100 threshold as a point where statin therapy becomes more strongly indicated.

How do age and sex affect interpretation of the same numerical score?

Calcium accumulates with age. A 70-year-old with a score of 100 has less calcium than most people his age, while a 45-year-old with the same score has far more than typical. Percentile rankings place an individual’s score in the context of their demographic peers, answering the question: compared to others of my age, sex, and ethnicity, where do I stand?

The MESA study established reference percentiles using data from a multiethnic cohort. These tables allow a score of 50 in a 50-year-old man to be expressed as, say, the 75th percentile, meaning 75% of similar men have lower scores. The same absolute score might represent the 95th percentile for a 45-year-old woman.

Research confirms that both absolute scores and percentiles predict events, but they capture different information. A high percentile indicates accelerated atherosclerosis relative to peers, which may warrant earlier or more aggressive intervention. A high absolute score indicates total disease burden, which correlates with event risk regardless of whether it is typical for age (LaMonte, 2005).

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What does a CAC percentile tell you that the raw score doesn’t?

The raw score measures disease burden in absolute terms. The percentile measures whether that burden is unusual for someone of your demographic profile. Both matter, but for different purposes. A 55-year-old man with a score of 200 has definite disease and elevated absolute risk. If his percentile is 50th, his rate of calcium accumulation is average for his age group. If his percentile is 90th, he has accumulated disease faster than most of his peers, suggesting more aggressive underlying atherosclerosis.

Percentile rankings prove particularly useful for younger patients. A 40-year-old with any calcium at all has a score that puts them above most of their peers, even if the absolute number looks modest. Studies in younger populations show that CAC detection rates remain low, so even small scores carry significance in this group (Feuchtner et al., 2021).

The MESA online calculator allows anyone to enter their age, sex, ethnicity, and CAC score to obtain their percentile ranking. This tool translates a single number into a more nuanced understanding of how an individual compares to a reference population.

What is the difference between having calcium and having obstructive disease?

Calcium indicates that atherosclerosis is present. It does not indicate how severely the artery has narrowed. A person with extensive calcification may have minimal obstruction because the artery has remodeled outward to accommodate plaque growth. Another person with less total calcium might have a focal severe stenosis.

Studies using CT angiography show that CAC scores correlate imperfectly with the presence of obstructive lesions. High scores increase the probability of significant stenosis, but the relationship is not deterministic. Someone with a score of 500 might have diffuse mild disease without any single lesion narrowing the artery more than 50% (Brix, 2024).

This distinction matters for understanding what CAC testing does and does not accomplish. CAC scoring identifies subclinical atherosclerosis and stratifies long-term risk. It is not a substitute for tests that evaluate blood flow or detect obstructive lesions. Patients with symptoms suggesting angina may need functional testing or anatomic imaging with CT angiography regardless of their CAC score.

Can you have a zero calcium score and still have significant heart disease?

A zero CAC score is reassuring but not a guarantee. Roughly 3-5% of people with zero calcium have some degree of non-calcified or soft plaque visible on CT angiography. Studies in symptomatic patients found that 7-10% of those with zero calcium had evidence of coronary artery disease when evaluated with contrast-enhanced imaging (Ergün et al., 2011).

Certain populations appear more vulnerable to disease despite zero calcium. Diabetics, younger individuals, and those with elevated Lp(a) may have non-calcified plaque without corresponding calcium. Research in younger symptomatic patients showed that the prevalence of non-calcified plaque increases with age even when calcium remains absent (Yu et al., 2021).

Heart attacks from soft plaque rupture can occur in people with zero or low CAC scores. These events are less common than in those with high scores, but they happen. A zero score dramatically reduces risk but does not eliminate it, particularly in the presence of other strong risk factors.

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What does soft plaque mean, and why doesn’t it show up on a CAC scan?

Atherosclerotic plaque exists on a spectrum from soft, lipid-rich lesions to dense calcified deposits. Soft plaque contains cholesterol, inflammatory cells, and fibrous tissue but has not yet accumulated enough calcium to be detected on a non-contrast CT scan. The CAC protocol specifically identifies calcified lesions and misses everything else.

Soft plaque matters because the lesions most prone to rupture and cause heart attacks often have lipid-rich cores with thin fibrous caps. These vulnerable plaques may contain little or no calcium. Studies following patients with zero calcium found that those who later experienced cardiac events often had non-calcified plaque visible on baseline CT angiography (Lee et al., 2013).

This limitation explains why a zero CAC score does not warrant abandoning all risk factor modification. Someone with zero calcium but multiple cardiac risk factors still benefits from lifestyle optimization and, in some cases, lipid-lowering therapy. The CAC score informs but does not replace a comprehensive risk assessment.

How does CAC scoring predict heart attack and cardiovascular mortality risk?

CAC scoring predicts events better than traditional risk factors alone. The landmark MESA study demonstrated that coronary calcium predicted heart attacks and coronary deaths across all ethnic groups, independent of standard risk factors like cholesterol, blood pressure, and smoking (Detrano, 2008). Adding CAC to the Framingham risk score improved prediction substantially.

The relationship between CAC and events follows a dose-response pattern. Analysis of over 44,000 asymptomatic individuals showed that all-cause mortality increased stepwise with higher CAC scores, even after adjusting for age, sex, and traditional risk factors (Nasir et al., 2012). The predictive value persists over long follow-up periods, with higher scores associated with greater risk for at least 15 years.

CAC also predicts stroke risk. A meta-analysis of over 13,000 individuals found that elevated CAC scores were associated with increased incident stroke, though the relationship was weaker than for coronary events (Chaikriangkrai et al., 2017). The systemic nature of atherosclerosis means coronary calcium reflects vascular disease elsewhere in the body.

Conclusion

Interpreting a CAC score requires understanding both the absolute number and its demographic context. The standard score categories provide rough benchmarks, but percentile rankings reveal whether your disease burden is typical or accelerated for your age and sex. A zero score is reassuring but does not exclude soft plaque or eliminate risk entirely.

The next step after receiving results is determining what action they warrant. For guidance on translating scores into treatment decisions, see What to Do With Your CAC Results. For comparison with other testing options, see CAC vs Other Cardiac Tests. Understanding these concepts positions you to have an informed conversation with your physician about your cardiovascular health.